Dimethyl Sulfoxide
Apexbio Technology LLC Vorapaxar 618385-01-6 10mM (in 1mL DMSO)
Vorapaxar (CAS 618385-01-6) is a selective inhibitor of protease-activated receptor 1 (PAR1) a G-protein coupled receptor activated by thrombin-mediated cleavage on platelet surfaces leading to platelet activation Derived from the natural product himbacine vorapaxar directly binds PAR1 inhibiting platelet aggregation induced by thrombin receptor-activating peptides (IC 25 nM) and thrombin itself (IC 47 nM) In phase III clinical trials in patients daily oral administration reduced the incidence of cardiovascular death or ischemic events highlighting its relevance as an antithrombotic research agent
Apexbio Technology LLC Nitrendipine 39562-70-4 10mM (in 1mL DMSO)
Nitrendipine (CAS number 39562-70-4) is a dihydropyridine derivative acting as a calcium channel antagonist that selectively inhibits L-type calcium channels By blocking calcium ion influx into vascular smooth muscle cells nitrendipine induces vasodilation and reduces peripheral vascular resistance thereby lowering arterial blood pressure Due to its vascular-selective calcium antagonism it serves as a pharmacological tool in cardiovascular research particularly for studying mechanisms of hypertension and calcium-dependent signaling pathways
Apexbio Technology LLC PD318088 391210-00-7 10mM (in 1mL DMSO)
PD318088 (CAS 391210-00-7) is an allosteric non-ATP competitive inhibitor of MEK1/2 kinase activity Structurally related to PD184352 it interacts adjacent to the ATP-binding site of MEK1 in proximity to residues Ile216 Phe209 Arg189 and Asp190 stabilizing a ternary complex involving MEK1/2 and MgATP This binding moderately increases the dissociation constant (Kd) for the MEK dimerization state from 75 nM to 140 nM PD318088 is mainly utilized as a molecular tool in protein kinase signaling research particularly in pathways involving MEK1/2
Apexbio Technology LLC Cyclophosphamide 50-18-0 10mM (in 1mL DMSO)
Cyclophosphamide is a nitrogen mustard alkylating prodrug activated via hepatic enzymes to its active metabolites These metabolites alkylate DNA primarily at guanine residues resulting in DNA cross-linking strand breaks and mutations consequently triggering cytotoxic effects Cyclophosphamide exhibits cytotoxicity in vitro with an IC50 of 37 6 M in mouse embryo BALB/c 3T3 cells and an IC50 of 8 79 M against human HL60 cells It impacts immune regulation by decreasing regulatory T cell counts and suppressive marker expression (FoxP3 GITR) facilitating immune response modulation Commonly applied in cancer and immunological research cyclophosphamide is also employed in genotoxicity assays due to its capacity to induce chromosomal aberrations and mutations
Apexbio Technology LLC Golvatinib (E7050) 928037-13-2 10mM (in 1mL DMSO)
Golvatinib (E7050 CAS 928037-13-2) is a small-molecule inhibitor targeting the tyrosine kinases c-Met and VEGFR-2 Golvatinib inhibits phosphorylation of c-Met in MKN45 gastric cancer cells and VEGFR-2 in human umbilical vein endothelial cells (HUVECs) with IC50 values of 14 nM and 16 nM respectively Additionally it suppresses proliferation of various tumor cells including MKN45 EBC-1 Hs746T and SNU-5 and inhibits tumor growth in xenograft models via reduction of c-Met and VEGFR-2-mediated pathways Golvatinib is utilized in cancer research to explore targeted antitumor efficacy related to angiogenesis and oncogenic signaling
Apexbio Technology LLC Carfilzomib (PR-171) 868540-17-4 10mM (in 1mL DMSO)
Carfilzomib (PR-171 CAS 868540-17-4) is a derivative of the natural product epoxomicin and functions as an irreversible inhibitor of the chymotrypsin-like activity within the 20S proteasome Proteasomes play a critical role in intracellular protein degradation thus inhibition results in accumulation of polyubiquitinated proteins Through this mechanism Carfilzomib induces cell cycle arrest and apoptosis consequently suppressing tumor cell growth Research applications primarily involve exploration of its antitumor efficacy and mechanisms in oncology models
Apexbio Technology LLC Simeprevir(Synonyms: Olysio, TMC435, TMC435350, Simeprevir sodium), 10mM (in 1mL DMSO), CAS: 923604-59-5.
Simeprevir (CAS 923604-59-5) is a small molecule inhibitor targeting the hepatitis C virus (HCV) NS3/4A protease a viral serine protease essential for viral polyprotein processing and replication Simeprevir inhibits NS3/4A protease with a Ki of 0 36 nM and demonstrates antiviral activity by reducing viral replication in Huh-7 replicon cells (EC50 of 7 8 nM) and Huh7-Luc HCV genotype 1b replicon cells (EC50 of 8 nM EC90 of 24 nM) Simeprevir is widely utilized in research on antiviral mechanisms and therapeutic strategies against HCV infections
Medchemexpress LLC Cimetidine sulfoxide | 54237-72-8 | 97.0% | C10H16N6OS | 10MG
Cimetidine sulfoxide is the sulfoxide metabolite of cimetidine provided for research and analytical applications (CAS 54237-72-8). Supplied as a research-grade solid, it is used as a reference standard in studies of histamine H2-receptor antagonists, drug metabolism, and analytical method development.
- High-purity reference standard suitable for analytical assays.
- Useful for metabolic and pharmacokinetic studies.
- Available in small milligram pack sizes for research use.
- Documentation available: COA, SDS, and handling instructions.
- Stable solid form for storage and long-term use.
Apexbio Technology LLC Olmesartan 144689-24-7 10mM (in 1mL DMSO)
Olmesartan (CAS 144689-24-7) is a small molecule angiotensin II receptor antagonist primarily acting by selectively blocking the binding of angiotensin II to AT1 receptors This mechanism interrupts angiotensin II-mediated vasoconstriction and aldosterone secretion resulting in antihypertensive effects In biomedical research Olmesartan serves as a valuable tool for examining hypertensive disease models elucidating angiotensin II signaling pathways and exploring therapeutic strategies targeting cardiovascular regulation
Apexbio Technology LLC Pioglitazone HCl 112529-15-4 10mM (in 1mL DMSO)
Pioglitazone HCl is a potent and highly selective agonist of the peroxisome proliferator-activated receptor gamma (PPAR ) a nuclear receptor involved in glucose and lipid metabolism regulation Acting via PPAR activation pioglitazone increases insulin sensitivity in hepatic adipose and peripheral tissues enhancing insulin-mediated glucose uptake and utilization Pioglitazone requires the presence of insulin to exert its biological activity through receptor activation limiting its application in scenarios characterized by substantial insulin deficiency Clinically pioglitazone HCl has been widely applied in the management and investigation of hyperglycemia associated with type 2 diabetes mellitus (T2DM) Additionally pioglitazone demonstrates effects on lipid regulation notably reducing triglyceride levels and increasing high-density lipoprotein (HDL) cholesterol making it useful in metabolic research
Apexbio Technology LLC c-Myc tag Peptide 2918768-02-0 10mM (in 1mL DMSO)
c-Myc tag peptide is a synthetic peptide with the amino acid sequence EQKLISEEDL corresponding to residues 410-419 at the C-terminal region of human c-Myc protein It serves as an epitope tag for recombinant protein expression enabling specific recognition and purification of fusion proteins using anti-c-Myc antibodies In immunoassays the peptide competitively binds to anti-c-Myc antibodies confirming antibody-antigen binding specificity and facilitating analysis of fusion proteins in Western blotting immunoprecipitation and immunofluorescence experiments c-Myc itself encodes a transcription factor regulating cellular processes such as proliferation growth apoptosis differentiation and stem-cell renewal pathways and is frequently overexpressed in cancers
Apexbio Technology LLC Quercetin(Synonyms: Sophoretin, Meletin, Quercetine, 3,3',4',5,7-Pentahydroxyflavone, Quercetol, Xanthaurine), 10mM (in 1mL DMSO), CAS: 117-39-5.
Quercetin (CAS 117-39-5) is a dietary flavonoid widely found in fruits vegetables nuts tea and red wine exhibiting notable antineoplastic and anti-inflammatory effects It functions primarily as a potent inhibitor of intracellular signaling kinases including PI3K and NF- B and moderately inhibits Akt1/2 with weaker effects on PKC p38 and ERK1/2 pathways Moreover quercetin can elevate cytosolic Ca levels disrupt mitochondrial membrane potential induce cytochrome c release and activate caspases (3 8 and 9) thereby promoting apoptosis through mitochondrial pathways It also affects cell cycle progression and apoptosis via stabilizing and phosphorylating p53 Thus quercetin serves as a valuable tool in cancer research providing insights into chemoprevention mechanisms and therapeutic potentials
Apexbio Technology LLC Cilengitide 188968-51-6 10mM (in 1mL DMSO)
Cilengitide (CAS 188968-51-6) is a cyclic RGD pentapeptide [Arg-Gly-Asp-DPhe-(NMeVal)] that acts as an inhibitor of integrins v 3 and v 5 These integrins are transmembrane receptors mediating cellular processes such as adhesion migration angiogenesis and invasion Cilengitide binds directly to v 3 integrin receptors inhibiting integrin-mediated activities with an IC50 of 250 nM In in vitro assays cilengitide dose-dependently reduces proliferation and adhesion of endothelial progenitor cells In vivo studies showed that cilengitide administration significantly lowered osteolytic lesion formation and soft tissue involvement in metastatic MDA-MB-231 tumor models
Apexbio Technology LLC Tipifarnib (Zarnestra) 192185-72-1 10mM (in 1mL DMSO)
Tipifarnib (Zarnestra CAS 192185-72-1) is an orally bioavailable imidazole quinolinone derivative specifically designed as a non-peptidomimetic inhibitor of the enzyme farnesyltransferase (FTase) FTase catalyzes the farnesylation of proteins essential for tumor cell proliferation and survival By selectively blocking FTase activity Tipifarnib disrupts downstream signaling pathways suppressing cellular proliferation and inducing apoptosis across diverse cancer cell types notably acute myeloid leukemia (AML) and multiple myeloma (MM) In preclinical models Tipifarnib demonstrates antiproliferative and pro-apoptotic activities supporting its utility in targeted cancer therapy research